As turbomachinery systems continue to push the limits of modern technology, the modeling techniques being developed also continue to push modern computational limits. While modeling the pristine system during the design process is important, it is equally important to model behavior of mistuned systems, due to wear or manufacturing processes. This work carries out a statistical analysis on a two-stage system consisting of integrally bladed rotors. Various forms of large geometric mistuning, such as missing mass, bends, and dents, are considered. These forms of large mistuning are based on previously reported damage seen in actual engines that have ingested volcanic ash. This work also aims to investigate the interaction of these large mistuned systems with various levels of small mistuning to further understand this complex interaction. For every case studied, a reduced-order model (ROM) will be constructed that includes the effects of small and large mistuning. Large mistuning will only be applied to a single sector of a single stage. Random patterns of small mistuning will be applied to each case of large mistuning after which a modal analysis and a forced response analysis are run. By observing the energy distribution of each mode for the mistuned system, a qualitative trend can be created between various types and levels of large mistuning and the impact they have on changing the dynamics of the multistage system. The amplification factors from the forced response analyses help in understanding the impact small mistuning has when coupled with large mistuning and when the effects of small mistuning dominate over the large mistuning effects.