A major consequence of stent implantation is restenosis that occurs due to neointimal formation. This patho-physiologic process of tissue growth may not be completely eliminated. Recent evidence suggests that there are several factors such as geometry and size of vessel, and stent design that alter hemodynamic parameters, including local wall shear stress distributions, all of which influence the restenosis process. The present three-dimensional analysis of developing pulsatile flow in a deployed coronary stent quantifies hemodynamic parameters and illustrates the changes in local wall shear stress distributions and their impact on restenosis. The present model evaluates the effect of entrance flow, where the stent is placed at the entrance region of a branched coronary artery. Stent geometry showed a complex three-dimensional variation of wall shear stress distributions within the stented region. Higher order of magnitude of wall shear stress of is observed on the surface of cross-link intersections at the entrance of the stent. A low positive wall shear stress of and a negative wall shear stress of are seen at the immediate upstream and downstream regions of strut intersections, respectively. Modified oscillatory shear index is calculated which showed persistent recirculation at the downstream region of each strut intersection. The portions of the vessel where there is low and negative wall shear stress may represent locations of thrombus formation and platelet accumulation. The present results indicate that the immediate downstream regions of strut intersections are areas highly susceptible to restenosis, whereas a high shear stress at the strut intersection may cause platelet activation and free emboli formation.
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e-mail: rupak.banerjee@uc.edu
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June 2006
Technical Papers
Developing Pulsatile Flow in a Deployed Coronary Stent
Divakar Rajamohan,
Divakar Rajamohan
Department of Mechanical Engineering,
University of Cincinnati
, Cincinnati, OH 45221
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Rupak K. Banerjee,
Rupak K. Banerjee
Department of Mechanical Engineering, and Department of Biomedical Engineering,
e-mail: rupak.banerjee@uc.edu
University of Cincinnati
, 688 Rhodes Hall, PO Box 210072, Cincinnati, OH 45221
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Lloyd H. Back,
Lloyd H. Back
Jet Propulsion Laboratory,
California Institute of Technology
, Pasadena, CA 91109
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Ashraf A. Ibrahim,
Ashraf A. Ibrahim
Department of Mechanical Engineering,
University of Cincinnati
, Cincinnati, OH 45221
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Milind A. Jog
Milind A. Jog
Department of Mechanical Engineering,
University of Cincinnati
, Cincinnati, OH 45221
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Divakar Rajamohan
Department of Mechanical Engineering,
University of Cincinnati
, Cincinnati, OH 45221
Rupak K. Banerjee
Department of Mechanical Engineering, and Department of Biomedical Engineering,
University of Cincinnati
, 688 Rhodes Hall, PO Box 210072, Cincinnati, OH 45221e-mail: rupak.banerjee@uc.edu
Lloyd H. Back
Jet Propulsion Laboratory,
California Institute of Technology
, Pasadena, CA 91109
Ashraf A. Ibrahim
Department of Mechanical Engineering,
University of Cincinnati
, Cincinnati, OH 45221
Milind A. Jog
Department of Mechanical Engineering,
University of Cincinnati
, Cincinnati, OH 45221J Biomech Eng. Jun 2006, 128(3): 347-359 (13 pages)
Published Online: November 9, 2005
Article history
Received:
August 6, 2004
Revised:
November 9, 2005
Citation
Rajamohan, D., Banerjee, R. K., Back, L. H., Ibrahim, A. A., and Jog, M. A. (November 9, 2005). "Developing Pulsatile Flow in a Deployed Coronary Stent." ASME. J Biomech Eng. June 2006; 128(3): 347–359. https://doi.org/10.1115/1.2194067
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