This paper provides a qualitative evaluation of the impact of advanced fuel cycles, particularly partition and transmutation of actinides, on the uncertainty associated with geologic disposal. Based on the discussion, advanced fuel cycles, will not materially alter (1) the repository performance, (2) the spread in dose results around the mean, (3) the modeling effort to include significant features, events, and processes in the performance assessment, or (4) the characterization of uncertainty associated with a geologic disposal system in the regulatory environment of the United States.

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