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research-article

Fabrication of Inner Grooved Hollow Fiber Membranes Using Microstructured Spinneret for Nerve Regeneration

[+] Author and Article Information
Jun Yin

The State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China; Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China; Department of Mechanical Engineering, Clemson University, Clemson, SC 29634, USA
junyin@zju.edu.cn

Zonghuan Wang

The State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China; Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China
wzhdzhxw@zju.edu.cn

Wenxuan Chai

Department of Mechanical Engineering, Clemson University, Clemson, SC 29634, USA; Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611, USA
wchai@ufl.edu

Guangli Dai

Department of Medical Engineering, Ningbo First Hospital, Ningbo 315010, China
daiguangli@126.com

Hairui Suo

The State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China; Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China
suohairui@zju.edu.cn

Ning Zhang

Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
nzhang2@vcu.edu

Xuejun Wen

Shanghai East Hospital, Institute for Biomedical Engineering and Nano Science (iNANO), Tongji Medical School, Tongji University, Shanghai 200120, China; Department of Chemical and Life Science Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
xwen@vcu.edu

Yong Huang

Department of Mechanical Engineering, Clemson University, Clemson, SC 29634, USA; Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611, USA
yongh@ufl.edu

1Corresponding author.

ASME doi:10.1115/1.4037430 History: Received May 08, 2017; Revised June 21, 2017

Abstract

Nerve conduits with topographical guidance have been recognized as the efficient repair of damaged peripheral nerves. In this study, polymeric hollow fiber membranes (HFMs) with grooved inner surface have been fabricated from a microstructured spinneret using a dry-jet wet spinning process for nerve regeneration studies. The effectiveness of HFM inner grooves has been demonstrated during an in vitro study of chick forebrain neuron outgrowth. It is of great importance that the groove geometry can be controllable to meet various needs in promoting nerve regeneration performance. While the overall groove geometry is determined by the spinneret design, fabrication conditions are also indispensable in fine-tuning the final groove geometry such as the groove height and width on the order of 10 µm or less. It is found that the bore fluid flow rate can be utilized to effectively adjust the resulting groove height by at most 52%, and groove width by at most 61%, respectively without modifying the spinneret geometry. This enables a new approach to fabricate different grooved HFMs using the same spinneret. By comparing to the influences of bore fluid flow rate, the dope fluid flow rate is less effective in regulating the groove height and width when using the same microstructured spinneret. If the groove width is to be finely tuned, the selection of both bore and dope fluid flow rates should be careful.

Copyright (c) 2017 by ASME
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