In this study a heat transfer model of machining of Ti-6Al-4V under the application of atomization-based cutting fluid spray coolant is developed to predict the temperature of the cutting tool. Owing to high tool temperature involved in machining of Ti-6Al-4V, the model considers film boiling as the major heat transfer phenomenon. In addition, the design parameters of the spray for effective cooling during machining are derived based on droplet-surface interaction model. Machining experiments are conducted and the temperatures are recorded using the inserted thermocouple technique. The experimental data are compared with the model predictions. The temperature field obtained is comparable to the experimental results, confirming that the model predicts tool temperature during machining with ACF spray cooling satisfactorily.