The paper describes process development for producing sound, strong, and ductile Nb pipe–316L stainless steel (SS) flange brazed joint suitable for application in superconducting radiofrequency (SRF) cavities. The developed transition joints, made with BVAg-8 braze filler metal (BFM), were free of brittle intermetallic compounds, in contrast to the existing global brazing practice of using oxygen-free electronic copper as BFM which results in the formation of a continuous layer of Fe–Nb brittle intermetallic compound at Nb–braze interface. In view of the large difference in the mean thermal expansion coefficients between niobium and 316L stainless steel, a new design for manufacturing and assembly (DFMA) has been developed to ensure achievement of desired joint thickness with uniformity in circumferential and longitudinal directions. An environment-friendly prebraze cleaning procedure has been qualified and implemented. DFMA has resulted in (i) significant reduction of the out-of-roundness errors (≤10 μm) while machining of the niobium pipe, (ii) simplified clearance fit prebraze assembly at room temperature (RT), and (iii) uniformity of joint thickness. A process flow chart has been developed to ensure repeatability of joint characteristics. The brazed joint, of niobium pipe and 100CF knife edge 316L SS flange made by standardized practice, displayed helium leak tightness better than 5 × 10−10 mbar l/s at RT and at liquid helium temperature (LHT). The braze-joint sustained 873 K/10 h postbraze hydrogen degassing treatment and thermal cycling between RT and LHT without any loss in hermeticity.