Selective laser melting (SLM) is widely used in making three-dimensional functional parts layer by layer. Temperature magnitude and history during SLM directly determine the molten pool dimensions and surface integrity. However, due to the transient nature and small size of the molten pool, the temperature gradient and the molten pool size are challenging to measure and control. A three-dimensional finite element (FE) simulation model has been developed to simulate multilayer deposition of Ti-6Al-4 V in SLM. A physics-based layer buildup approach coupled with a surface moving heat flux was incorporated into the modeling process. The melting pool shape and dimensions were predicted and experimentally validated. Temperature gradient and thermal history in the multilayer buildup process was also obtained. Furthermore, the influences of process parameters and materials on the melting process were evaluated.