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Research Papers

Bioprinting Technology: A Current State-of-the-Art Review

[+] Author and Article Information
Amer B. Dababneh

Mechanical and Industrial
Engineering Department,
The University of Iowa,
Iowa City, IA 52242
Biomanufacturing Laboratory,
Center for Computer-Aided Design,
The University of Iowa,
Iowa City, IA 52242

Ibrahim T. Ozbolat

Mechanical and Industrial
Engineering Department,
The University of Iowa,
Iowa City, IA 52242
Biomanufacturing Laboratory,
Center for Computer-Aided Design,
The University of Iowa,
Iowa City, IA 52242
e-mail: ibrahim-ozbolat@uiowa.edu

1Corresponding author.

Contributed by the Manufacturing Engineering Division of ASME for publication in the JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING. Manuscript received April 15, 2014; final manuscript received August 24, 2014; published online October 24, 2014. Assoc. Editor: David L. Bourell.

J. Manuf. Sci. Eng 136(6), 061016 (Oct 24, 2014) (11 pages) Paper No: MANU-14-1211; doi: 10.1115/1.4028512 History: Received April 15, 2014; Revised August 24, 2014

Bioprinting is an emerging technology for constructing and fabricating artificial tissue and organ constructs. This technology surpasses the traditional scaffold fabrication approach in tissue engineering (TE). Currently, there is a plethora of research being done on bioprinting technology and its potential as a future source for implants and full organ transplantation. This review paper overviews the current state of the art in bioprinting technology, describing the broad range of bioprinters and bioink used in preclinical studies. Distinctions between laser-, extrusion-, and inkjet-based bioprinting technologies along with appropriate and recommended bioinks are discussed. In addition, the current state of the art in bioprinter technology is reviewed with a focus on the commercial point of view. Current challenges and limitations are highlighted, and future directions for next-generation bioprinting technology are also presented.

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Figures

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Fig. 1

Classification of bioprinting techniques

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Fig. 2

Inkjet-based bioprinting: (a) a schematic of thermal-based inkjet bioprinting, (b) a schematic of piezoelectric-based inkjet bioprinting, (c) microscopic top views of a complete 3D multicell “pie” construct using an inkjet-based bioprinter (courtesy of Elsevier [54]), and (d) a tubular structure of the printed human microvasculature using an inkjet-based bioprinter (courtesy of Elsevier [57])

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Fig. 3

Laser-based bioprinting: (a) a schematic of laser-based bioprinting (LDW and LAB), (b) different cell types printed in close contact to each other with a high cell concentration (courtesy of Elsevier [74]), (c) chondrocytes stained with Calcein, and (d) osteoblast cells stained with Dil-LDL

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Fig. 4

Extrusion-based bioprinting: (a) a schematic of extrusion-based bioprinting technique, (b) a cell-laden structure consisting of chondrocytes and osteoblasts was produced using an extrusion-based bioprinter (courtesy of Jin-Hyung Shim)

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Fig. 5

Cell-aggregate-based bioink: (a) tissue spheroids (150 μm in diameter): human primary brain endothelial cells (outermost layer), human primary pericytes cells (middle layer), human primary astrocytes cells (hpAs) (innermost layer), and the complete spheroid composed of all three cell types (courtesy of Elsevier [143]), (b) cell pellet in a syringe, and (c) tissue strands

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Fig. 6

Bioprinters: (a) Palmetto Bioprinter (courtesy of Michael J. Yost), (b) MtoBS (courtesy of Jin-Hyung Shim), and (c) the MABP

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Fig. 7

Commercial bioprinters: (a) NovoGen MMX Bioprinter (courtesy of Organovo, San Diego, CA), (b) fourth generation 3D Bioplotter (courtesy of Envisiontec GmbH, Gladbeck, Germany), and (c) Sciperio/nScrypt (courtesy of BioAssembly Tool, Orlando, FL)

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