Due to the complexity of multiphase flows, they are often studied with numerical simulations. These simulations must be validated with experimental results. This paper introduces a new approach to initialize the continuous phase of gas–liquid flows generated by airblast nozzles for microlubrication applications with a recently modified commercial computational fluid dynamics (CFD) code FINE™/Open. Microlubrication is a technology used in metal machining where the coolant flow rate is lower than with conventional flood cooling. In this paper, single-phase gas and two-phase liquid–gas flows are studied. The continuous phase is simulated using Reynolds-averaged Navier–Stokes (RANS) equations coupled with a k–ε turbulence model and the dispersed phase is simulated using a Lagrangian method. To validate these simulations, particle image velocimetry (PIV) and particle dynamics analysis (PDA) measurements have been performed. This study illustrates the possibility of performing complex two-phase simulations with the help of single-phase studies to initialize the continuous phase of the flow (i.e., the gas). The single-phase flow also helps in estimating the magnitudes of the droplet velocities.