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Research Papers

Modeling of Bubble Expansion-Induced Cell Mechanical Profile in Laser-Assisted Cell Direct Writing

[+] Author and Article Information
Wei Wang, Gang Li

Department of Mechanical Engineering, Clemson University, Clemson, SC 29634

Yong Huang1

Department of Mechanical Engineering, Clemson University, Clemson, SC 29634yongh@clemson.edu

1

Corresponding author.

J. Manuf. Sci. Eng 131(5), 051013 (Sep 24, 2009) (10 pages) doi:10.1115/1.4000101 History: Received September 04, 2008; Revised July 28, 2009; Published September 24, 2009

Cell damage due to the mechanical impact during laser-assisted cell direct writing has been observed and is a possible hurdle for broad applications of fragile cell direct writing. The objective of this study is to numerically investigate the bubble expansion-induced cell mechanical loading profile in laser-assisted cell direct writing. Some conclusions have been drawn as follows. The cell velocity increases initially and then smoothes out gradually with a constant ejection velocity. Both the cell acceleration and pressure can be very high at the beginning period of bubble expansion and then quickly approach zero in an oscillation manner. A high viscosity can lead to an observable velocity increment at the initial stage, but the ejection velocity decreases. The pressure magnitude decreases when the cell-bubble distance is large, and a larger initial pressure induces a larger cell pressure as expected. This study serves as a foundation to further investigate the cell damage mechanism in laser-assisted cell direct writing to improve the effectiveness and efficiency of cell direct writing techniques.

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Copyright © 2009 by American Society of Mechanical Engineers
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Figures

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Figure 1

(a) Cell direct writing schematic and (b) modeling domain for the bubble expansion-induced cell deformation

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Figure 2

Computational flow chart of bubble dynamics equation

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Figure 3

Cell center velocity comparison under a 221 MPa initial bubble pressure

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Figure 4

(a) Coupled Lagrangian and Eulerian computational domains and (b) distribution of cell elements

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Figure 5

Evolution of cell center velocity

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Figure 6

Evolution of cell center acceleration

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Figure 7

Cell pressure at different cell internal regions

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Figure 8

(a) Cell center velocity, (b) cell center acceleration, and (c) cell pressure under different coating viscosity conditions (the initial pressure is 22.1 MPa and the cell-bubble distance is 55 μm)

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Figure 9

(a) Cell center velocity, (b) cell center acceleration, and (c) cell pressure under different cell-bubble distances (the initial pressure is 22.1 MPa and the coating viscosity is 12×10−3 Pa s)

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Figure 10

(a) Cell center velocity, (b) cell center acceleration, and (c) cell pressure under different initial bubble pressures (the coating viscosity is 12×10−3 Pa s and the cell-bubble distance is 55 μm)

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