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Technical Briefs

Modeling of Flow Rate, Pore Size, and Porosity for the Dispensing-Based Tissue Scaffolds Fabrication

[+] Author and Article Information
M. G. Li

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, S7N 5A9, Canadamil715@mail.usask.ca

X. Y. Tian, X. B. Chen

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, S7N 5A9, Canada

J. Manuf. Sci. Eng 131(3), 034501 (Apr 30, 2009) (5 pages) doi:10.1115/1.3123331 History: Received July 13, 2008; Revised February 24, 2009; Published April 30, 2009

Dispensing technique is one of the promising solid freeform (SFF) methods to fabricate scaffolds with controllable pore sizes and porosities. In this paper, a model to represent the dispensing-based SFF fabrication process is developed. Specifically, the mechanical properties of the scaffold material and its influence on the fabrication process are examined; the flow rate of the scaffold material dispensed and the pore size and porosity of the scaffold fabricated in the process are represented. In order to generate scaffold strands without either tensile or compressive stress, the optimal moving speed of the dispensing head is determined from the flow rate of the scaffold material dispensed. Experiments were also carried out to illustrate the effectiveness of the model developed.

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Copyright © 2009 by American Society of Mechanical Engineers
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Figures

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Figure 1

Schematic of scaffolds made by SFF technique: (a) overview and (b) internal structure

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Figure 2

Typical curve of strain versus stress

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Figure 3

Schematic of dispenser

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Figure 4

(a) Schematic of the strands in contact and (b) contact surfaces

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Figure 5

Flow rate under different applied air pressures (45% HA-chitosan gel)

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Figure 6

Flow rate at different HA volume fractions (pressure=3.5 bars)

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Figure 7

Measured and predicted pore sizes

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Figure 8

Measured and predicted porosities

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Figure 9

Scaffolds made by using different colloids: (a) with lower τe and (b) with higher τe

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