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Research Papers

Parametric Study of Acoustic Excitation-Based Glycerol-Water Microsphere Fabrication in Single Nozzle Jetting

[+] Author and Article Information
C. Leigh Herran, Wei Wang

Department of Mechanical Engineering, Clemson University, Clemson, SC 29634

Yong Huang1

Department of Mechanical Engineering, Clemson University, Clemson, SC 29634yongh@clemson.edu

Vladimir Mironov, Roger Markwald

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425

1

Corresponding author.

J. Manuf. Sci. Eng 132(5), 051001 (Sep 10, 2010) (7 pages) doi:10.1115/1.4002187 History: Received January 19, 2009; Revised June 21, 2010; Published September 10, 2010; Online September 10, 2010

Microspheres or droplets are increasingly finding various biomedical applications as drug microspheres and multicellular spheroids. Single nozzle-based continuous jetting with the help of acoustic excitation and/or carrier stream is a basic process for monodisperse microsphere fabrication. Precise control of microsphere size and size distribution in single nozzle jetting is still of great manufacturing interest. The objective of this study is to numerically model a glycerol-water microsphere fabrication process during acoustic excitation-based single nozzle continuous jetting. Using a volume of fluid method, this study has investigated the effects of material properties and fabrication conditions such as the acoustic excitation frequency and amplitude and the carrier stream velocity on the size of microspheres fabricated. (1) The microsphere diameter decreases as the glycerol volume percentage increases. (2) The excitation frequency and pressure have a pronounced effect on the microsphere size. The microsphere diameter decreases as the excitation frequency increases, and the microsphere diameter increases with the excitation pressure amplitude. (3) The microsphere size decreases as the carrier stream velocity increases.

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Copyright © 2010 by American Society of Mechanical Engineers
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Figures

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Figure 1

Schematic of the microsphere fabrication process

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Figure 2

Schematic of computational setup

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Figure 3

Comparison of microsphere diameter predictions for different glycerol percentage solutions

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Figure 5

Microsphere diameter as a function of excitation frequency

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Figure 6

Logarithmic relationship comparison of the microsphere diameter versus the reciprocal of excitation frequency

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Figure 7

Microsphere diameter versus the excitation pressure amplitude

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Figure 8

Microsphere diameter versus the carrier stream velocity

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Figure 4

Microsphere diameter as a function of glycerol percentage

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