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Research Papers

Replication Quality of Flow-Through Microfilters in Microfluidic Lab-on-a-Chip for Blood Typing by Microinjection Molding

[+] Author and Article Information
Bong-Kee Lee

Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-Dong, Nam-Gu, Pohang, Gyungbuk 790-784, Korea

Chul Jin Hwang

Precision Mold Technology Team, Korea Institute of Industrial Technology (KITECH), 193 Yakdae-Dong, Wonmi-Gu, Buchen, Gyeonggi-Do 420-734, Korea

Dong Sung Kim1

School of Mechanical Engineering, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul 156-756, Koreasmkds@cau.ac.kr

Tai Hun Kwon1

Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-Dong, Nam-Gu, Pohang, Gyungbuk 790-784, Koreathkwon@postech.ac.kr

1

Corresponding authors.

J. Manuf. Sci. Eng 130(2), 021010 (Mar 25, 2008) (8 pages) doi:10.1115/1.2896142 History: Received July 24, 2007; Revised January 08, 2008; Published March 25, 2008

In the present study, replication of flow-through microfilters in the newly developed microfluidic lab-on-a-chip for blood typing by microinjection molding process was experimentally investigated. As a precise replication of the microfilters was required in order to effectively filter out agglutinated red blood cells, the effects of important processing conditions on the replication of the flow-through microfilters were investigated. By using a mold insert fabricated by a nickel electroplating process and a newly designed mold base, microinjection molding experiments were carried out. A three-dimensional solid model reconstruction method was proposed with the help of specific features characterizing the geometry of microfilters, and accordingly, the feature values of the replicated microfilters were measured by a noncontact optical measurement system. So reconstructed solid modeling result was then used to investigate the effects of various processing conditions, such as a flow rate, a mold temperature, and a packing pressure. Amongst the processing conditions investigated in the present study, the flow rate was found to be the most important one.

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Copyright © 2008 by American Society of Mechanical Engineers
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Figures

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Figure 1

(a) Schematic diagram of the disposable microfluidic lab-on-a-chip for blood typing developed in Ref. 5 and (b) cross sectional view (a-a′ in (a)) of flow-through microfilters in the microfluidic lab-on-a-chip before and after a thermal bonding

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Figure 2

SEM image of the microcavities for the flow-through microfilters in the electroplated nickel mold insert

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Figure 3

Fabricated mold base: (a) schematic view and (b) detailed view of the mold insert block

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Figure 4

SEM images of the replicated microfilters (a) for the processing condition of Q=44cm3∕s, Tw=130°C, Pp=50MPa; (b) enlarged view of (a); (c) for the processing condition of Q=8cm3∕s, Tw=100°C, Pp=0MPa; (d) enlarged view of (c)

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Figure 5

(a) Microcavity for the typical micropost of the flow-through microfilter in the mold insert and its detailed dimensions; (b) Case I, flat top surface and its characteristic feature values; (c) Case II, round top surface and its characteristic feature values

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Figure 6

Effect of the flow rate Q (without the packing stage) for the case of Tw=100°C

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Figure 7

Effect of mold temperature Tw (without the packing stage): (a) Q=8cm3∕s, (b) Q=17cm3∕s, and (c) Q=44cm3∕s

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Figure 8

Effect of the packing pressure Pp: (a) Tw=100°C, (b) Tw=115°C, and (c) Tw=130°C

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Figure 9

Three-dimensional plots of the FVFs for the different processing conditions

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Figure 10

Investigations of the effects of three processing parameters based on Taguchi method (a) S/N ratios for the processing parameters and (b) chart for the contribution ratios

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