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Research Papers

Designed PCL Nanofibers Fabricated Using a Modified Electrohydrodynamic Process for Tissue Engineering

[+] Author and Article Information
GeunHyung Kim1

Nature-Inspired Bio-Mechanical Team, Division of Nano Mechanical System, Korea Institute of Machinery and Materials (KIMM), 171 Jang-dong, Yuseong-gu, Daejeon 305-343, Koreagkim@kimm.re.kr

WanDoo Kim

Nature-Inspired Bio-Mechanical Team, Division of Nano Mechanical System, Korea Institute of Machinery and Materials (KIMM), 171 Jang-dong, Yuseong-gu, Daejeon 305-343, Korea

1

Corresponding author.

J. Manuf. Sci. Eng 130(2), 021006 (Mar 20, 2008) (6 pages) doi:10.1115/1.2896108 History: Received March 30, 2007; Revised December 12, 2007; Published March 20, 2008

An ideal scaffold should have good mechanical properties and provide a biologically functional implant site. Considering their large surface area, high porosity, and good interconnectivity of pores, electrospun micro-∕nanofibers have good potential as biomimic scaffolds. In this study, various poly(ε-carprolactone) webs consisting of uniaxially oriented micro-∕nanofibers were produced using an electrohydrodynamic process (electrospinning) with a conical electrode and two-axis collector. The oriented fibrous web showed mechanical orthotropic properties, which might be important for designing engineering scaffolds that mimic natural tissues, such as a blood vessel or ligament, which have orthotropic mechanical properties. In addition, the fabricated mats, which were electrospun using computer-assisted design, had good hydrophilic and good cellular behavior compared to a random fiber mat.

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Copyright © 2008 by American Society of Mechanical Engineers
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Figures

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Figure 1

Schematic diagram of the electrospinning process showing a conical electrode and two-axis collector

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Figure 4

Shapes of electrospun fiber mats deposited using the conical electrode and moving x‐y collector with (a) a fixed stage, (b) a rounded stage moving at 25cm∕s, and (c) a stage controlled using the CAD system

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Figure 3

Photographs of the Taylor cone at the nozzle tip: (a) standard electrospinning and ((b)–(d)) modified electrospinning using a conical electrode and three different projections of the nozzle under the same applied electric voltage of 15kV. (e) Comparison of the diameters of the electrospun fibers. (f) An area deposited using electrospinning with a conical electrode (the nozzle tip protruded about 5mm from the edge of the conical electrode) with an applied voltage of 15.3kV and 200mm distance between the nozzle and ground. (g) An area of electrospun nanofibers deposited on a PET film using the standard electrospinning method.

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Figure 2

(a) EFCF and calculated electric field at the nozzle tip for different nozzle positions within a conical electrode. (b) Process diagram of the critical voltage needed to generate uniform micro-∕nanosized fibers.

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Figure 6

WCA of (a) randomly deposited fibers, and fibers aligned (b) parallel or (c) perpendicular to the direction of target plate movement. (d) Comparison of the WCA measured at 0min and 5min.

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Figure 7

SEM micrographs showing the interaction between HDFs and (a) nonaligned and (b) aligned nanofibers after three days of culture

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Figure 8

The proliferation of human dermal fibroblasts seeded on electrospun pure and aligned PCL nanofiber webs

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Figure 5

Dynamic mechanical result of a PCL nanofiber mat electrospun using a stage moving at 25cm∕s, in which the fibers are deposited parallel (∥) and perpendicular (⊥) to the direction of target plate movement

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