Two laser transmission welding experiments involving polyvinyl chloride are presented that aim to validate a previously presented welding model while helping to further understand the relationship between welding parameters and weld quality. While numerous previous research papers have presented the results of laser welding experiments, there exists minimal work validating models of the welding process. The first experiment explores the interaction of laser power and welding velocity while the second experiment explores the influence of clamping pressure. Using the weld width as the primary model output, the agreement between the welding experiments and the model have an average error of 5.6%. This finding strongly supports the validity of the model presented in Part I of this two paper set (Van de Ven and Erdman, 2007, ASME J. Manuf. Sci. Eng., 129, pp. 849–858). Additional information was gained regarding the operating window for laser transmission welding and the thermal decomposition of polyvinyl chloride. Clamping pressure was found to provide a small, but not statistically significant, influence on the visual appearance, weld width, and weld strength.