Computer numerically controlled manufacturing equipment and tooling has led to process automation and significant productivity advances. Demand for high quality products and cost-effective processes continues to grow and has driven the design of new machinery, intelligent tooling, and sophisticated control and automation techniques. However, the efficiency and throughput of modern manufacturing processes still depends on the interaction of the machine and the process. This motivates research in the area of process–machine interaction. This special issue provides a platform to disseminate recent research efforts that increase our understanding of this interaction. The paper topics are wide ranging, but may be arranged by discipline.